Belonging to a class of drugs called azole antifungals, Fluconazole is known to treat serious fungal or yeast infections. It finds widespread usage in treating infections like vaginal candidiasis, oropharyngeal candidiasis (thrush, oral thrush), esophageal candidiasis (candida esophagitis) and other candida infections, including urinary tract infections, peritonitis, or fungal (cryptococcal) meningitis. It is usually available in tablet and powder for suspension dosage forms. 
Patients under the treatment of bone marrow transplantation or under cytotoxic chemotherapy (in conjunction with radiation therapy) may be predisposed to candida infections and hence may be prescribed with Fluconazole. This drug has also proved its efficacy in treating serious fungal infections in the lungs that spread through the body and manifest as infections of the eye, skin and nails. It is also used to prevent fungal infections in patients who are already suffering from HIV or cancer. 
Mechanism of action
The drug has demonstrated to show fungistatic activity against strains of the following: Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis and Cryptococcus neoformans. The mechanism of action is steroidal inhibition in fungal cells that interferes with cell wall synthesis, growth and cell adhesion, therefore treating fungal infections and their symptoms. The drug is a very selective inhibitor of the fungal cytochrome P450 dependent enzyme lanosterol 14-α-demethylase which converts lanosterol to ergosterol, essential for fungal cell wall synthesis. 
It is usually consumed once a day, with or without food, as prescribed by the physician. Before using the drug, it is advised to inform the doctor about any known source of allergies, or other drugs that the patient might be exposed to. The actual dosage depends on:
- The age of the patient
- Conditions being treated
- Severity of the condition
- Other underlying medical conditions
- Reaction to the first dose
Completing the prescribed dose is recommended, even if the symptoms disappear after a few days. Stopping the medication early will fuel fungal growth, which may result in the return of the infection. [4, 5]
These are some common side effects of Fluconazole that range from mild to severe. Some of the notable ones include: 
- Nausea, vomiting, diarrhea, stomach upset, stomach pain
- Headache, dizziness
- Hair loss
- Loss of appetite
- Unusual tiredness
- Weight loss
- Fast/irregular heartbeat
- Yellowing of eyes or skin
- Dark-coloured urine
It is advised to contact the physician immediately if any of these above symptoms are experienced.
- It is always advisable to visit the doctor before taking the medicine and informing him of the patient’s medical history.
- The drug might lead to allergic reactions if you are allergic to Fluconazole or any other azole antifungal drug, or have a history of any allergy in general.
- Informing your doctor of any existing or past history of liver and kidney disease is advisable.
- This drug also may cause a condition that affects the heart rhythm: QT prolongation. It may be the reason of fast/irregular heartbeat and other symptoms such as severe dizziness and fainting.
- Limit alcoholic beverages and stop cannabis consumption if you are on fluconazole prescription.
- If consumed within three months of pregnancy, this medication could harm the child, and hence should be used only when needed and under the doctor’s supervision. Fluconazole also passes into breast milk but is unlikely to harm a nursed infant, although the physician’s advice is once again recommended. 
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Shubham Pharmachem’s blog posts have been written with the information gathered from approved medical journals and websites online. Our research and technical team strives to provide relevant information through such articles. We strongly advise readers to not consume or administer any medication without prior consultation with their doctor.
Mayo Clinic [online]: https://www.mayoclinic.org/drugs-supplements/fluconazole-oral-route/proper-use/drg-20071428?p=1
Medline Plus [online]: https://medlineplus.gov/druginfo/meds/a690002.html
 DrugBank [online]: https://go.drugbank.com/drugs/DB00196
Medical News Today [online]: https://www.medicalnewstoday.com/articles/fluconazole-oral-tablet#dosage